CITRAPHERES 4%®

Sodium Citrate 4%
Product information
CITRAPHERES 4%
Sodium Citrate 4%
Medical device, Class IIb
Product composition
The solution contains sodium citrate dihydrate (Ph. Eur.).
The solution pH is adjusted by means of citric acid monohydrate (Ph.Eur.).
Sodium Citrate dihydrate 40.0 g
Citric Acid monohydrate 0.3 g
Water for injection add 1000 ml
pH ≈ 7.0
Osmolality: 539.5 mOsm/l
Pharmaceutical form of product
The anticoagulant 4 % sodium citrate dihydrate solution is a sterile clear solution, free from bacterial endotoxins. It is packed in transparent bags .
Instructions for use Continuous blood cleansing methods
The solution should be added to blood flowing into the device (venous blood usually) depending on the planned anticoagulation level. The ratio of the solution volume to blood quantity should be determined by the physician indicating the elimination method. One part of 4 % sodium citrate dihydrate solution to 30-40 parts of whole blood is usually used.
The continuous elimination therapy as such should be performed in accordance with instructions for use provided by the manufacturer of each given elimination device.
The amount of 4 % sodium citrate dihydrate solution used during the elimination procedure must be included in the overall fluid balance.
Apheresis procedure by means of a device: The solution should be added to venous blood before apheresis in a ratio ensuring the planned anticoagulation degree. Such ratio must be determined by the physician responsible for the apheresis. One part of the anticoagulant 4 % sodium citrate dihydrate solution to 15 parts of blood is usually used during such procedures.